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Consensus nomenclature for the mammalian methionine adenosyltransferase genes and gene products

โœ Scribed by Malak Kotb; S.Harvey Mudd; Jose M. Mato; Arthur M. Geller; Nicholas M. Kredich; Janice Y. Chou; Gulio L. Cantoni


Book ID
114173719
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
209 KB
Volume
13
Category
Article
ISSN
0168-9525

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Hepatic stellate cell (HSC) activation is an essential event during liver fibrogenesis. Methionine adenosyltransferase (MAT) catalyzes biosynthesis of S-adenosylmethionine (SAMe), the principle methyl donor. SAMe metabolism generates two methylation inhibitors, methylthioadenosine (MTA) and S-adenos