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Consecutive isomerization and cyclization of 3-(2-aminophenyl)-1-arylprop-2-yn-1-ols leading to 2-arylquinolines in the presence of potassium hydroxide

✍ Scribed by Chan Sik Cho; Na Young Lee; Tae-Jeong Kim; Sang Chul Shim

Publisher: Journal of Heterocyclic Chemistry
Year: 2004
Tongue: English
Weight: 108 KB
Volume: 41
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570410317

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✦ Synopsis

Abstract

3‐(2‐Aminophenyl)‐1‐arylprop‐2‐yn‐1‐ols are readily converted to 2‐arylquinolines in good yields in ethanol at 80° in the presence of potassium hydroxide via domino isomerization and cyclization.

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