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Consecutive and domino processes for the synthesis of a heavily functionalised tricyclic system

✍ Scribed by Emanuela Marotta; Paolo Righi; Goffredo Rosini

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 273 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)10698-0

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✦ Synopsis

One pot multi-bond forming reactions are one of the ways to address the ever growing demand for efficiency in organic synthesis that concern the chemical commtmity. This paper presents a new threecomponent domino process that efficiently combines four bond-forming reaction steps into a single synthetic operation. From easily available linear starting materials and under very mild conditions, this process builds five new bonds end four new chirai centers, giving rise to the selective formation of a new class of fused beteroatomic tricyclic systera, which may be exploited for the synthesis of biologically interesting aminopolyhydroxylated compounds.

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