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Conomicidines A and B, Unusual Alkaloid–Hydroxycinnamyl Alcohol Conjugates from Tabernaemontana corymbosa

✍ Scribed by Kuan-Hon Lim; Toh-Seok Kam

Publisher: John Wiley and Sons
Year: 2009
Tongue: German
Weight: 184 KB
Volume: 92
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200900093

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✦ Synopsis

Abstract

Conomicidines A and B (1a and 2a, resp.) together with the diastereomeric isoconomicidines A and B (1b and 2b, resp.) were isolated from Tabernaemontana corymbosa as unresolvable mixtures of the (1′S,2′S)‐ and (1′R,2′R)‐diastereoisomers (i.e., 1a and 1b; 2a and 2b). These novel natural products are constituted from the union of an iboga alkaloid, ibogaine, and hydroxycinnamyl alcohol moieties, and represent the first examples of such alkaloid–hydroxycinnamyl alcohol conjugates. The structures were determined by spectroscopic methods, including the extensive use of NOE experiments for the assignment of the configuration.

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ChemInform Abstract: Conomicidines A and

ChemInform Abstract: Conomicidines A and B, Unusual Alkaloid—Hydroxycinnamyl Alcohol Conjugates from Tabernaemontana corymbosa

✍ Kuan-Hon Lim; Toh-Seok Kam 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 21 KB 👁 2 views

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