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Connectivity of Neutral Networks, Overdispersion, and Structural Conservation in Protein Evolution

✍ Scribed by Ugo Bastolla; Markus Porto; Markus H. Eduardo Roman; Michele H. Vendruscolo

Publisher
Springer
Year
2003
Tongue
English
Weight
247 KB
Volume
56
Category
Article
ISSN
0022-2844

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πŸ“œ SIMILAR VOLUMES

Neutral Evolution of Model Proteins: Dif
Neutral Evolution of Model Proteins: Diffusion in Sequence Space and Overdispersion
✍ Ugo Bastolla; H.Eduardo Roman; Michele Vendruscolo πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 English βš– 244 KB

We stimulate the evolution of model protein sequences subject to mutations. A mutation is considered neutral if it conserves (1) the structure of the ground state, (2) its thermodynamic stability and (3) its kinetic accessibility. All other mutations are considered lethal and are rejected. We adopt