Connective Tissue Growth Factor (CTGF/CCN2) Mediates Angiogenic Effect of S1P in Human Dermal Microvascular Endothelial Cells

Hyaluronic acid modulates gene expressio

Hyaluronic acid modulates gene expression of connective tissue growth factor (CTGF), transforming growth factor-β1 (TGF-β1), and vascular endothelial growth factor (VEGF) in human fibroblast-like synovial cells from advanced-stage osteoarthritis in vitro

✍ Yu-Tsang Lee; Hung-Jen Shao; Jyh-Horng Wang; Haw-Chang Liu; Sheng-Mou Hou; Tai-H 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 275 KB

Intraarticular injection of hyaluronan (hyaluronic acid; HA) is the common way to treat osteoarthritis (OA) of knees. This treatment cannot only maintain the viscoelastic properties of knee but also release the OA pain. However, the exact molecular mechanism is unknown. In this study, after human sy