Conjugation of acetylcholine receptor-protecting Fab fragments with polyethylene glycol results in a prolonged half-life in the circulation and reduced immunogenicity

Long circulating half-life and high tumo

Long circulating half-life and high tumor selectivity of the photosensitizer meta-tetrahydroxyphenylchlorin conjugated to polyethylene glycol in nude mice grafted with a human colon carcinoma

✍ Patrick Westermann; Thomas Glanzmann; Snezana Andrejevic; Daniel R. Braichotte; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 272 KB 👁 2 views

In a model of nude mice bearing a human colon carcinoma xenograft, the biodistribution and tumor localization of metatetrahydroxyphenylchlorin (m-THPC) coupled to polyethylene glycol (PEG) were compared with those of the free form of this photosensitizer used in photodynamic therapy (PDT). At differ