Conjugates of stimuli-responsive polymers and proteins

✍ Scribed by Allan S. Hoffman; Patrick S. Stayton

• Publisher: Elsevier Science
• Year: 2007
• Tongue: English
• Weight: 234 KB
• Volume: 32
• Category: Article
• ISSN: 0079-6700
• DOI: 10.1016/j.progpolymsci.2007.05.005

✦ Synopsis

This chapter focuses on the synthesis and applications of covalent conjugates of proteins and stimuli-responsive or ''smart'' polymers. Smart polymer-drug conjugates are included only when the drug is a protein. The conjugation of biotinylated smart polymers to streptavidin is included, as is the use of streptavidin to link a biotinylated protein and a biotinylated smart polymer. Proteins that are conjugated with poly(ethylene glycol) (PEG), or ''PEGylated'' proteins, are not included in this chapter since PEG is not utilized as a smart polymer in such conjugates. Smart polymer-protein conjugates immobilized on solid surfaces or within hydrogels are also not included, unless they represent the ''phaseseparated state'' of the reversible soluble-insoluble phases of the conjugate.