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Conjugate addition to chromones: Synthesis of substituted 4-chromanones

โœ Scribed by Timothy W. Wallace


Book ID
104233789
Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
184 KB
Volume
25
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


Chromones activated by carbonyl substituents at C-3 are transformed into the corresponding B-methyl 4-chromanones by treating with lithium dimethylcuprate


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swrunary Improved use of organocopper reagents provides a generaI route to unsynunetrical 2,2-diaZkyZchromanones and thiochromanones from chromones and thiochromones via a simple addition -oxidation -addition sequence