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Conjugate-addition reactions of organometallic reagents to γ-oxygenated-α,β-unsaturated sulfones: Control of stereochemistry at the β-position

✍ Scribed by J.C. Saddler; P.C. Conrad; P.L. Fuchs

Publisher
Elsevier Science
Year
1978
Tongue
French
Weight
238 KB
Volume
19
Category
Article
ISSN
0040-4039

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✦ Synopsis

The key step in our recently developed synthesis of a,B-difunctionalized enones (2) from B-epoxysulfones (1) involves the conjugate-addition reaction of organolithium reagents to y-oxidoa,B-unsaturated

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Conjugate-addition reactions of highly-f
Conjugate-addition reactions of highly-functionalized aryl lithium reagents to γ-silyloxy-α,β-unsaturated sulfones: consequences of the structure of the sulfone moiety.
✍ D.L. Barton; P.C. Conrad; P.L. Fuchs 📂 Article 📅 1980 🏛 Elsevier Science 🌐 French ⚖ 224 KB

The effect of sulfone structure (phenyl vs t-butyl) is compared in the conjugateaddition reactions of ortho substituted and ortho, ortho disubstituted aryl lithium reagents -with y-silyloxy-a,@-unsaturated sulfones. Our earlier reports on the use of y-oxido-a,B-unsaturated sulfones (& n=5,6,7