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Conjugate addition of isocyanides to chromone 3-carboxylic acid: an efficient one-pot synthesis of chroman-4-one 2-carboxamides

✍ Scribed by Neo, Ana G.; Díaz, Jesús; Marcaccini, Stefano; Marcos, Carlos F.


Book ID
119955370
Publisher
Royal Society of Chemistry
Year
2012
Tongue
English
Weight
948 KB
Volume
10
Category
Article
ISSN
1477-0520

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Silica sulfuric acid efficiently catalyzes the three-component Biginelli reaction between an aldehyde, a b-dicarbonyl compound and urea or thiourea in refluxing ethanol to afford the corresponding dihydropyrimidinones in high yields. The catalyst is reusable and can be applied several times without