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Congenital thyroxine binding globulin deficiency: incidence and inheritance

✍ Scribed by Malcolm B. Jenkins; Michael W. Steffes

Book ID
104704606
Publisher
Springer
Year
1987
Tongue
English
Weight
491 KB
Volume
77
Category
Article
ISSN
0340-6717

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✦ Synopsis

Ninety-nine cases of thyroxine binding globulin (TBG) deficiency (90 males and 9 females) were identified among low-T4 infants after newborn hypothyroid screening. The data indicate that inherited TBG deficiency occurs in at least 1:5,000 newborns (1:2,800 males) and that mild and more pronounced forms are found in approximately equal proportions. Genetic analysis indicates that X-linked inheritance is the usual mode with no suggestion of autosomal inheritance.

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