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Congenital Lack of COX-2 Affects Mechanical and Geometric Properties of Bone in Mice

โœ Scribed by Q. Chen; J. Y. Rho; Z. Fan; S. J. F. Laulederkind; R. Raghow


Book ID
105912974
Publisher
Springer
Year
2003
Tongue
English
Weight
150 KB
Volume
73
Category
Article
ISSN
1432-0827

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Inducible cyclo-oxygenase (COX-2) mediat
โœ M. R. Forwood ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› American Society for Bone and Mineral Research ๐ŸŒ English โš– 576 KB

In vivo, indomethacin blockade of bone formation has been used to illustrate the role of prostaglandins. Indomethacin blocks the constitutive (COX-1) and inducible (COX-2) forms of cyclo-oxygenase, and is therefore nonspecific in its action. To test the hypothesis that COX-2 mediates the bone format