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Congenital heart defects, maternal homocysteine, smoking, and the 677 C>T polymorphism in the methylenetetrahydroflate reductase gene: Evaluating gene-environment interactions

✍ Scribed by Charlotte A. Hobbs; S. Jill James; Stefanie Jernigan; Stepan Melnyk; Yunxia Lu; Sadia Malik; Mario A. Cleves


Book ID
113429526
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
178 KB
Volume
194
Category
Article
ISSN
1097-6868

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Evaluation of C677T and A1298C polymorph
✍ Ana Paula Carneiro Brandalize; Eliane Bandinelli; Pollyanna Almeida dos Santos; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 119 KB 👁 1 views

## Abstract Abnormal folate/homocysteine metabolism due to polymorphisms in genes involved in this pathway has been implicated as an etiologic factor in Down syndrome (DS). This case–control study aimed to evaluate the effect of maternal C677T and A1298C polymorphisms of the methylenetetrahydrofola