Congenital dyserythropoietic anemia type III associated with congenital atrioseptal defect has led to severe cardiac problems in a 32-year-old patient
✍ Scribed by G. Röhrig; H. Kilter; D. Beuckelmann; A. Kröner; C. Scheid; V. Diehl; D. Söhngen
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 708 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
We report the case of a 32-year-old woman who was admitted at hospital because of ortho-dyspnea, arrhythmia, and paleness. Clinical examination showed continuous arrhythmia, systolic heart murmur, enlargement of spleen and liver, and pathologic hematological parameters, thus indicating an intravasal hemolysis (elevated HBDH, bilirubin, and reticulocytes; reduced hemoglobin and haptoglobin levels), and bone-marrow-smears showed a typical cytomorphology of CDA III. The patient's diagnosis was heart failure caused by mitral valve insufficiency due to congenital atrioseptal defect associated with congenital dyserythropoietic anemia type III (CDA III).