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Congenital DNA repair deficiency results in protection against renal ischemia reperfusion injury in mice

✍ Scribed by Denis Susa; James R. Mitchell; Marielle Verweij; Marieke Van De Ven; Henk Roest; Sandra Van Den Engel; Ingeborg Bajema; Kirsten Mangundap; Jan N. M. IJzermans; Jan H. J. Hoeijmakers; Ron W. F. De Bruin


Book ID
111199531
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
413 KB
Volume
8
Category
Article
ISSN
1474-9718

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Apoptosis appears to be a central mechanism of cell death following reperfusion of the ischemic liver. The aim of this study was to determine the effect of decreased expression of the proapoptotic Bax gene on hepatic apoptotic warm ischemia/reperfusion (I/R) injury. Three groups of mice were studied