Congenital cytomegalic inclusion disease

✍ Scribed by Vassella, F. ;Rossi, E.

• Book ID: 104775741
• Publisher: Springer-Verlag
• Year: 1971
• Weight: 367 KB
• Volume: 109
• Category: Article
• ISSN: 0044-2917
• DOI: 10.1007/bf00442266

✦ Synopsis

Of a total of 30 infants and children with eytomegaloviruria 19 were considered to suffer from comlatal disease. This assumption was based either on clinical findings present already during the neonatal period or on signs of prenatal infection. The most common clinical sign was hepatomegaly, followed in decreasing order by developmental retardation, abnormal neurological findings, splenomegaly, epilepsy, microcephaly, jaundice, interstitial pneumonia, intraeerebral calcifications, chorioretinitis, malformations, hydrocephalus, lymphocytic meningitis and thrombopenia. 13 of the 19 infants had CF antibody titers of 1:30 or greater, but 3 patients had no detectable CF antibodies. Titers showed a tendency to decrease in the course of the months. Cytomegalovirttria in a child was still present after 27 months. The duration of virus excretion and CF antibody titer could not be correlated with the severity of the illness.