Congenital chloride diarrhoea in Kuwaiti children

✍ Scribed by M. M. Lubani; K. I. Doudin; D. C. Sharda; A. A. Shaltout; T. S. Al-Shab; Y. K. Abdul Al; M. A. Said

• Book ID: 104776705
• Publisher: Springer
• Year: 1989
• Tongue: English
• Weight: 361 KB
• Volume: 148
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00444128

✦ Synopsis

Congenital chloride diarrhoea was diagnosed in 16

Knwaiti children over a 7 year period (1980)(1981)(1982)(1983)(1984)(1985)(1986)) with an estimated incidence of 7.6 per 100,000 live births. The mean age at diagnosis was 3.2 months (range 1 week to 5 months). There were 9 boys and 7 girls with a mean age of 3 years 10 months (range 10 months to 7 years). All children had a shortened gestational period, abdominal distension and chronic diarrhoea. The serum electrolytes in all patients prior to treatment showed hyponatraemia, hypokalaemia, hypochloraemia and metabolic alkalosis. The diagnosis was confirmed by a stool chloride content that exceeded the sum of faecal sodium and potassium. Fifteen patients survived and showed catch-up growth with adequate replacement therapy and 1 died with renal failure.