𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Conformer equilibria of triostin A and its conformer-specific interaction with nucleic acid bases

✍ Scribed by Yoshimasa Kyogoku; Naoki Higuchi; Mayumi Watanabe; Keiichi Kawano

Publisher
Wiley (John Wiley & Sons)
Year
1981
Tongue
English
Weight
587 KB
Volume
20
Category
Article
ISSN
0006-3525

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A quinoxaline antibiotic triostin A has a bicyclic octadepsipeptide structure. Proton and carbon‐13 nmr spectra showed the presence of two symmetrical conformations favoring polar and nonpolar solvents, respectively. They interconvert slowly on the nmr time scale, and this slow interconversion is due to the cooperative effects of the presence of the quinoxaline ring and the N‐methyl peptide bonds. Reversal of the chirality of the disulfide bond as the origin of the slow exchange was excluded by the presence of two conformers for S‐benzyltriostin A. Conformer 2, which favors the polar solvent, can form hydrogen‐bonded complexes with purine nucleoside derivatives in organic solvents, but conformer 1 does not. The binding sites were elucidated and a mode of interaction with DNA proposed.

📜 SIMILAR VOLUMES

Reversible Conformational Transitions of
Reversible Conformational Transitions of a Polymer Brush Containing Boronic Acid and its Interaction with Mucin Glycoprotein
✍ Alexander E. Ivanov; Nadezda Solodukhina; Marie Wahlgren; Lars Nilsson; Alexande 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 604 KB

## Abstract Reversible changes of the height of a polymer brush containing phenylboronic acid were studied. The polymer brush thickness underwent reversible changes of 0.5–1 nm, in response to the changes in composition of the contacting aqueous phase from deionized water to bicarbonate buffer and

Protein–nucleic acid interactions and DN
Protein–nucleic acid interactions and DNA conformation in a complex of human immunodeficiency virus type 1 reverse transcriptase with a double-stranded DNA template-primer
✍ Jianping Ding; Stephen H. Hughes; Edward Arnold 📂 Article 📅 1997 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 721 KB

The conformation of the DNA and the interactions of the nucleic acid with the protein in a complex of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) and a 19-mer/18-mer double-stranded DNA template-primer (dsDNA) are described. The structure of this HIV-1 RT complex with dsDN

Volume changes correlate with entropies
Volume changes correlate with entropies and enthalpies in the formation of nucleic acid homoduplexes: Differential hydration of A and B conformations
✍ Dionisios Rentzeperis; Donald W. Kupke; Luis A. Marky 📂 Article 📅 1993 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 827 KB

## Abstract We have used a combination of densimetric, calorimetric, and uv absorption techniques to obtain a complete thermodynamic characterization for the formation of nucleic acid homoduplexes of known sequence and conformation. The volume change Δ__V__ accompanying the formation of four duplex

A post-SCF quantum chemistry study on lo
A post-SCF quantum chemistry study on local minima of 8-oxo-guanine stacked with all four nucleic acid bases in B-DNA conformations
✍ Piotr Cysewski; Żaneta Czyżnikowska-Balcerak 📂 Article 📅 2007 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 488 KB

## Abstract magnified image The post SCF MP2/6‐31G\*(d=0.25) method was applied to obtain potential energy surface of 8‐oxoguanine stacked with all four canonical DNA bases. The spatial neighbourhood was scanned of stacked complexes found in the native B‐DNA. The presented results suggest that the

Dependence of purine 8C-H exchange on nu
Dependence of purine 8C-H exchange on nucleic acid conformation and base-pairing geometry: A dynamic probe of DNA and RNA secondary structures
✍ James M. Benevides; George J. Thomas Jr. 📂 Article 📅 1985 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 931 KB

## Synopsis Laser Raman spectroscopy is employed as a probe of hydrogen isotope exchange in nucleic acids exhibiting different secondary structures. The rates for deuterium exchange of 8GH groups in adenine (A), hypoxanthine (I), and guanine (G) residues of r i b and deoxyribopolynucleotides are c