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Conformationally Constrained Analogues of Diacylglycerol. 20. The Search for an Elusive Binding Site on Protein Kinase C through Relocation of the Carbonyl Pharmacophore Along the sn -1 Side Chain of 1,2-Diacylglycerol Lactones

โœ Scribed by Tamamura, Hirokazu; Sigano, Dina M.; Lewin, Nancy E.; Blumberg, Peter M.; Marquez, Victor E.

Book ID
127358582
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
209 KB
Volume
47
Category
Article
ISSN
0022-2623

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Conformationally Constrained Analogues o
Conformationally Constrained Analogues of Diacylglycerol. 18. The Incorporation of a Hydroxamate Moiety into Diacylglycerol-Lactones Reduces Lipophilicity and Helps Discriminate between sn-1 and sn-2 Binding Modes to Protein Kinase C (PK-C). Implications for Isozyme Specificity.
โœ Lee, Jeewoo; Han, Kee-Chung; Kang, Ji-Hye; Pearce, Larry L.; Lewin, Nancy E.; Ya ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› American Chemical Society ๐ŸŒ English โš– 11 KB