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Conformational variability of Gly-Gly segments in peptides: A comparison of the crystal structures of an acyclic pentapeptide and an octapeptide

✍ Scribed by Saumen Datta; N. Shamala; Arindam Banerjee; P. Balaram

Publisher: Wiley (John Wiley & Sons)
Year: 1997
Tongue: English
Weight: 115 KB
Volume: 41
Category: Article
ISSN: 0006-3525
DOI: 10.1002/(sici)1097-0282(199703)41:3<331::aid-bip8>3.0.co;2-t

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✦ Synopsis

Octapeptide

The crystal structure of an acyclic pentapeptide, Boc-Gly-Gly-Leu-Aib-Val-OMe, reveals an extended conformation for the Gly-Gly segment, in contrast to the helical conformation determined earlier in the octapeptide Boc-Leu-Aib-Val-Gly-Gly-Leu-Aib-Val-OMe [I. L. Karle, A. Banerjee, S. Bhattacharjya, and P. Balaram [1996]