## Abstract Thiosemicarbazones are having the ability to bind with metal and inhibit the enzyme ribonucleoside diphosphate reductase (RDR), an enzyme which is involved in the synthesis of DNA precursors in the mammalian cells. The title compound Nโmethylโtโ3โmethylโrโ2, cโ6โdiphenylpiperidinโ4โone
Conformational study of some N-acyl-2r,6c-diphenylpiperidin-4-one oximes using NMR spectra
โ Scribed by J. Chakkaravarthy; G. Muthukumaran; K. Pandiarajan
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 267 KB
- Volume
- 889
- Category
- Article
- ISSN
- 0022-2860
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A series of __N__โarylsulfonylโ__t__(3)โisopropylโr(2),__c__(6)โdiarylpiperidinโ4โones 1โ8 were synthesized and characterized unambiguously by ^1^H, ^13^C NMR, 2DโCOSY and HSQC NMR spectroscopy. The conformational preferences of 1โ8 have been discussed on the basis of the coupling constants, and the
The NOESY spectrum and vicinal coupling constants of t(4)-acetoxy-3,3-dimethyl-r(2),c(6)-diphenyl-Nacetylpiperidine suggest that the compound adopts a chair conformation with axial phenyl groups. The vicinal coupling constants of t(4)-acetoxy-r(2),c(6)-diphenyl-N-acetylpiperidine could be accounted