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Conformational study of AZT in aqueous solution and adsorbed on a silver surface by means of Raman spectroscopy

✍ Scribed by Laura Rivas; Santiago Sanchez-Cortes; José V. García-Ramos

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
114 KB
Volume
33
Category
Article
ISSN
0377-0486

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✦ Synopsis

Abstract

The adsorption and conformation of the anti‐HIV drug AZT, and also thymine and 2′‐deoxythymidine, were studied on Ag colloids by surface‐enhanced Raman spectroscopy, showing that the conformational change induced by the adsorption on an Ag surface is similar to that induced by an alkaline pH, both related to deprotonation of the N‐3 atom leading to the C‐3′‐endo conformer. Copyright © 2002 John Wiley & Sons, Ltd.

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