✦ LIBER ✦

Conformational study of 1,4-thiazinan-3-one

✍ Scribed by Jorma K. Koskimies; Aija Halonen

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 536 KB
Volume: 3
Category: Article
ISSN: 1042-7163
DOI: 10.1002/hc.520030104

No coin nor oath required. For personal study only.

✦ Synopsis

The protori NMR spectra of several 1,4-thiazinan-3ones were analyzed using LAOCOON. The geminul and vicinal coupling constants indicate that the ring conformation of this heterocycle is a half-chair similar to 6-valerolactam. Molecular mechanics calculations show that the energy ofthe boat is only slightly higher thaii that ofthe half-chair. The confomzational equilibria of methyl-substituted compounds were culculated by the coupling constant method. These energies are conipared to those obtained by molecular mec ha n ics.

MacroModel Energies (kJ) Calculated for

Compound

Chair Boat

📜 SIMILAR VOLUMES

Synthesis of 2-Selenoxo-1,3-thiazolidin-

Synthesis of 2-Selenoxo-1,3-thiazolidin-4-ones and 2-Selenoxo-1,3-thiazinan-4-ones from Isoselenocyanates.

✍ Geoffroy L. Sommen; Anthony Linden; Heinz Heimgartner 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 18 KB 👁 1 views

A DIC mediated expeditious small library

A DIC mediated expeditious small library synthesis and biological activity of thiazolidin-4-one and 1,3-thiazinan-4-one derivatives

✍ Amit Verma; Shweta S Verma; Shailendra K Saraf 📂 Article 📅 2010 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 183 KB

## Abstract magnified image A diisopropylcarbodiimide (DIC) mediated small library of thiazolidin‐4‐one and 1,3‐Thiazinan‐4‐one derivatives were efficiently synthesized using one pot three component condensation of amino acid, aldehyde, and mercapto carboxylic acid on a polymer support. The study s

Synthese und Eigenschaften von 4-Alkoxy-

Synthese und Eigenschaften von 4-Alkoxy-5-imino-1,4-thiazinan-3-onen

✍ Detlef Geffken; Hans-Jürgen Kämpf 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 347 KB 👁 2 views

ChemInform Abstract: Design and Synthesi

ChemInform Abstract: Design and Synthesis of 3-Alkyl-2-aryl-1,3-thiazinan-4-one Derivatives as Selective Cyclooxygenase (COX-2) Inhibitors.

✍ Tannaz Zebardast; Afshin Zarghi; Bahram Daraie; Mehdi Hedayati; Orkideh G. Dadra 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 27 KB 👁 2 views

ChemInform Abstract: Microwave-Induced S

ChemInform Abstract: Microwave-Induced Synthesis of Spiro[indoline-3,2′-[1,3]thiazinane]-2,4′-diones.

✍ Anshu Dandia; Mitali Saha; Babita Rani 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB 👁 1 views

One-Pot Synthesis of Functionalized (4-O

One-Pot Synthesis of Functionalized (4-Oxo-1,3-thiazinan-5-yl)acetic Acids from Isothiocyanates, Primary Alkylamines, and Ithaconic Anhydride

✍ Issa Yavari; Mohammad J. Bayat; Sanaz Souri; Mehdi Sirouspour 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 German ⚖ 148 KB 👁 1 views

## Abstract A one‐pot synthesis of 2‐(4‐oxo‐1,3‐thiazinan‐5‐yl)acetic acids is described __via__ a three‐component reaction between primary alkylamines and ithaconic anhydride and phenyl isothiocyanate or benzoyl isothiocyanate.