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Conformational studies of nikkomycin X in aqueous solution

✍ Scribed by Eduardo Krainer; Fred Naider; Jeffrey M. Becker

Publisher
Wiley (John Wiley & Sons)
Year
1990
Tongue
English
Weight
646 KB
Volume
29
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

Nikkomycin X is a peptidyl‐nucleoside antibiotic that inhibits chitin synthesis in fungi. Information on its conformation in aqueous solution was obtained from pH titration studies in which the nmr shifts of exchangeable and nonexchangeable protons were monitored. These studies and nuclear Overhauser effects support an unfolded or conformationally flexible structure for the antibiotic, and the syn and anti conformations of the nucleoside moiety were found to coexist. The conformation of the ribose ring was determined using a two‐state model; a slight shift from type N to type S conformers occurred as the pH was raised from 1 to 6.

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