Conformational Studies of N 3 -Substituted [1,3,4]-Oxadiazinan-2-ones
β Scribed by Casper, David M.; Blackburn, Jennifer R.; Maroules, Christopher D.; Brady, Tana; Esken, Joel M.; Ferrence, Gregory M.; Standard, Jean M.; Hitchcock, Shawn R.
- Book ID
- 127204218
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 151 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0022-3263
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## Abstract [1,3,4]βOxadiazinanβ2βones bearing substitution at the N~4~βposition have been synthesized from norephedrine in good yield __via N__βalkylation, nitrosation, reduction and cyclization.
Substituents placed on the phenyl rings of 2,3-diphenyl-1,3-thiazolidin-4-one affect the electron density surrounding both the methine proton and the C(2) carbon. These changes are reflected in the differing chemical shifts for these atoms relative to the parent compound. The other carbons in the he