✦ LIBER ✦
Conformational Studies of (±)-11,12-Didehydro-11-deoxycorynoline and (+)-11,13-Didehydro-11-deoxychelidonine, Hexahydrobenzo[c]phenanthridine-Type Alkaloid Derivatives, by X-Ray Crystal Structure and NMR Analyses
✍ Scribed by Miyoko Kamigauchi; Yukiko Maekawa; Chisato Tode; Yasuko In; Toshimasa Ishida
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- German
- Weight
- 253 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
The X‐ray crystal analyses of the two 11‐deoxy‐didehydrohexahydrobenzo[c]phenanthridine‐type alkaloid derivatives 3 and 4, derived from (±)‐corynoline (1) and (+)‐chelidonine (2), established their structures as (±)‐(5b__RS__,12b__RS__)‐5b,12b,13,14‐tetrahydro‐5b,13‐dimethyl[1,3]benzodioxolo[5,6‐c]‐1,3‐dioxolo[4,5‐i]phenanthridine (3) and (+)‐rel‐(12b__R__)‐7,12b,13,14‐tetrahydro‐13‐methyl[1,3]benzodioxolo[5,6‐c]‐1,3‐dioxolo[4,5‐i]phenanthridine (4). The conformations of 3 and 4 in CDCl~3~ were determined on the basis of ^1^H‐ and ^13^C‐NMR spectroscopy.