Conformational studies of enkephalins are hampered by their high flexibility which leads to mixtures of quasi-isoenergetic conformers in solution and makes NOEs very difficult to detect in NMR spectra. In order to improve the quality of the NMR data, Leu -enkephalin was synthesized with 15 N-labelle
Conformational Sampling of Bioactive Molecules: A Comparative Study.
β Scribed by Dimitris K. Agrafiotis; Alan C. Gibbs; Fangqiang Zhu; Sergei Izrailev; Eric Martin
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 18 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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Cyclolinopeptide A, a cyclic nonapeptide, was isolated in 1956 from linseed oil.' In 1966 Prox and Weygand' determined the amino acid composition and they elucidated the sequence of the peptide, demonstrating the following chemical structure: \*Dedicated to the memory of Professor F. Weygand.