Conformational restrictions of biologically active peptides via amino acid side chain groups
β Scribed by Victor J. Hruby
- Book ID
- 118941354
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 649 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0024-3205
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A novel type of conformationally restricted peptides with the structure of H-D-Xaa-Phe-NH-CH 2 -C 6 H 5 has been developed as inhibitors of serine proteinase chymotrypsin. The D-Xaa-alkyl and Phe-phenyl groups resulted in a formation of the hydrophobic core due to the side-chain-side-chain CH/ inter