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Conformational requirements for the polymerization of hemoglobin S: Studies of mixed liganded hybrids

โœ Scribed by Robert M. Bookchin; Ronald L. Nagel


Book ID
118917474
Publisher
Elsevier Science
Year
1973
Tongue
English
Weight
527 KB
Volume
76
Category
Article
ISSN
0022-2836

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Monte Carlo simulations have been performed to study the conformations of the pentapeptide fragments of normal adult (Thr-Pro-Glu-Glu-Lys) and sickle-like anemia hemoglobin (Thr-Pro-Val-Glu-Lys). The results show that the energy optimized conformation of normal adult hemoglobin-fragment agrees with