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Conformational requirements for molecular recognition of acetylcholine receptor main immunogenic region (MIR) analogues by monoclonal anti-MIR antibody: A two-dimensional nuclear magnetic resonance and molecular dynamics approach

โœ Scribed by Vassilios Tsikaris; Evangelos Detsikas; Maria Sakarellos-Daitsiotis; Constantinos Sakarellos; Efstratia Vatzaki; Socrates J. Tzartos; Michel Marraud; Manh Thong Cung


Publisher
Wiley (John Wiley & Sons)
Year
1993
Tongue
English
Weight
890 KB
Volume
33
Category
Article
ISSN
0006-3525

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## Monoclonal antibodies against the main immunogenic region (MIR) of the muscle acetylcholine receptor (AChR) are capable of inducing experimental myasthenia gravis ( M G ) in animals. The epitope of these antibodies has been localized between residues 67 and 76 of the AChR a-subunit. The conformat