Conformational properties of angiotensin II and its active and inactive TOAC-labeled analogs in the presence of micelles. Electron paramagnetic resonance, fluorescence, and circular dichroism studies

Conformational basis for the biological

Conformational basis for the biological activity of TOAC-labeled angiotensin II and bradykinin: Electron paramagnetic resonance, circular dichroism, and fluorescence studies

✍ Shirley Schreier; Simone R. Barbosa; Fábio Casallanovo; Renata de F. F. Vieira; 📂 Article 📅 2004 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 220 KB 👁 2 views

## Abstract N‐Terminally and internally labeled analogues of the hormones angiotensin (AII, DRVYIHPF) and bradykinin (BK, RPPGFSPFR) were synthesized containing the paramagnetic amino acid 2,2,6,6‐tetramethylpiperidine‐1‐oxyl‐4‐amino‐4‐carboxylic acid (TOAC). TOAC replaced Asp^1^ (TOAC^1^‐AII) and