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Conformational Preferences of Neurotransmitters: Ephedrine and Its Diastereoisomer, Pseudoephedrine

✍ Scribed by Butz, Patrick; Kroemer, Romano T.; Macleod, Neil A.; Simons, John P.


Book ID
126018954
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
119 KB
Volume
105
Category
Article
ISSN
1089-5639

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πŸ“œ SIMILAR VOLUMES


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## Abstract Proton NMR spectra suggest that the conformation with __trans__ vicinal hydrogens is favored for ephedrine as the free base in deuterium oxide, although in non‐polar solvents, such as deuteriotrichloromethane, the __gauche__ vicinal hydrogen conformations are favored, as has been report

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The conformational constraints imposed by 7-1actams in peptides have been studied using valence force field energy calculations and flexible geometry maps. It has been found that while cyclisation restrains the ~u of the lactam, non-bonded interactions contribute to the constraints on ~0 of the lact