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Conformational preferences in the Ser133-phosphorylated and non-phosphorylated forms of the kinase inducible transactivation domain of CREB

✍ Scribed by Ishwar Radhakrishnan; Gabriela C Pérez-Alvarado; H.Jane Dyson; Peter E Wright


Book ID
117109340
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
360 KB
Volume
430
Category
Article
ISSN
0014-5793

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Btk is a member of the Tec family of protein tyrosine kinases expressed in B cells. It is stimulated following cross-linking of the B cell receptor which leads to the autophosphorylation of a specific residue in the SH3 domain, Y223. Previous work using Btk-derived fusion proteins has shown that the