𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Conformational Origin of the Aggregation of Recombinant Human Factor VIII†

✍ Scribed by Grillo, Adeola O.; Edwards, Karen-Leigh T.; Kashi, Ramesh S.; Shipley, Krista M.; Hu, Lina; Besman, Marc J.; Middaugh, C. Russell

Book ID
111885111
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
123 KB
Volume
40
Category
Article
ISSN
0006-2960

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Influence of aggregation on immunogenici
Influence of aggregation on immunogenicity of recombinant human Factor VIII in hemophilia A mice
✍ Vivek S. Purohit; C. Russell Middaugh; Sathyamangalam V. Balasubramanian 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 221 KB

Recombinant human factor VIII (rFVIII), a multidomain glycoprotein is used in replacement therapy for treatment of hemophilia A. Unfortunately, 15%-30% of the treated patients develop inhibitory antibodies. The pathogenesis of antibody development is not completely understood. The presence of aggreg

Effect of metal cations on the conformat
Effect of metal cations on the conformation and inactivation of recombinant human factor VIII
✍ Tiffany S. Derrick; Ramesh S. Kashi; Manzer Durrani; Ashish Jhingan; C. Russell 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 138 KB

Heavy metals have been implicated in the aggregation of proteins and the pathophysiology of several neurodegenerative diseases. Herein, we describe the interaction of recombinant human factor VIII (rhFVIII) with Al þ3 , Tb þ3 , Co þ2 , and Fe þ3 using a combination of intrinsic fluorescence, circula