𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Conformational Modularity of an Abiotic Secondary-Structure Motif in Aqueous Solution

✍ Scribed by Andrew J. Zych; Brent L. Iverson

Publisher
John Wiley and Sons
Year
2002
Tongue
German
Weight
164 KB
Volume
85
Category
Article
ISSN
0018-019X

No coin nor oath required. For personal study only.

✦ Synopsis

Dedicated to Dieter Seebach on the occasion of his 65th birthday

We have investigated an abiotic secondary structure based on the stacking of alternating electron-rich (1,5dialkoxynaphthalene (Dan)) and electron-deficient (1,4,5,8-naphthalene-tetracarboxylic diimide (Ndi) benzo [lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetrone) aromatic units. Previously, the specifics of conformational behavior were uncovered in the minimal folding unit, namely the dimer, consisting of one Dan and one Ndi unit linked through various amino acid residues. Here is reported the investigation of a series of larger oligomers (trimers and tetramers) composed of selected dimer units. We determined that some of the larger oligomers displayed conformational modularity, that is, the persistence of subunit-conformational propensities when those subunits were used as components of larger structures. Conformational modularity can be viewed as a desirable property of folding molecules because it simplifies not only the design of larger, more complex oligomers, but also the structural analyses of such species.

📜 SIMILAR VOLUMES

Secondary structure of pig skin proteode
Secondary structure of pig skin proteodermatan sulfate: A perspective from Raman spectroscopic studies in aqueous solution
✍ V. Renugopalakrishnan; S. Zheng; A. T. Tu; S. P. Damle 📂 Article 📅 1989 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 255 KB 👁 2 views

Raman spectroscopic studies of pig skin proteodermatan sulfate in H,O are indicative of a well defined secondary structure consisting of a-helical, P-turn, and possibly "random" structures. The above conclusion is surprisingly close to the secondary structure of the "core" protein of pig skin proteo

An infrared study on the conformation of
An infrared study on the conformation of poly-L-proline in concentrated aqueous salt solutions
✍ Charles A. Swenson 📂 Article 📅 1971 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 341 KB 👁 1 views

The infrared absorption of poly-L-proline in concentrated aqueous salt solutions was measured in the fundanierital region. Of primary interest were the carbonyl absorption of the peptide linkage and the methylene C-H bending absorption of the pyrrolidine ring. These spectral regions each show an add

ChemInform Abstract: Solid-State and Sol
ChemInform Abstract: Solid-State and Solution Structure of the Salinomycin—Sodium Complex: Stabilization of Different Conformers for an Ionophore in Different Environments.
✍ E. F. PAULUS; M. KURZ; H. MATTER; L. VERTESY 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 25 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v