Glycosaminoglycans (GAGs), including heparin (A), are linear oligosaccharides that consist of amino sugars and uronic acids. [1] Many glycosaminoglycans are involved in vital biological functions [2] but still, little is known about the molecular mechanisms responsible for their action. Much progres
Conformational Locking of the Glycosyl Acceptor for Stereocontrol in the Key Step in the Synthesis of Heparin
โ Scribed by Hernan A. Orgueira; Alessandra Bartolozzi; Peter Schell; Peter H. Seeberger
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 103 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Statins are inhibitors of 3โhydroxyโ3โmethylโglutaryl coenzyme A reductase (HMGโCoA reductase) and became the standard of care for treatment of hypercholesterolemia because of their efficacy, safety, and longโterm benefits. They are administered as diastereoโ and enantiomerically pure c
We have used organic synthesis to understand the role of liduronic acid conformational flexibility in the activation of antithrombin by heparin. Among known synthetic analogues of the genuine pentasaccharidic sequence representing the antithrombin binding site of heparin, we have selected as a refer