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Conformational Equilibria in Monomeric α-Synuclein at the Single-Molecule Level

✍ Scribed by Sandal, Massimo; Valle, Francesco; Tessari, Isabella; Mammi, Stefano; Bergantino, Elisabetta; Musiani, Francesco; Brucale, Marco; Bubacco, Luigi; Samorì, Bruno

Book ID
120374908
Publisher
Public Library of Science
Year
2008
Tongue
English
Weight
428 KB
Volume
6
Category
Article
ISSN
1544-9173

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## Abstract α‐synuclein (α‐Syn) is an abundant brain protein whose mutations have been linked to early‐onset Parkinson's disease (PD). We recently demonstrated, by means of a single‐molecule force spectroscopy (SMFS) methodology, that the conformational equilibrium of monomeric wild‐type (WT) α‐Syn