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Conformational effects of Cα,α-dipropargylglycine as a constrained residue

✍ Scribed by L. Damodharan; K. Mohanraja; S. Kotha; S. Durani; V. Pattabhi

Book ID
101336527
Publisher
Wiley (John Wiley & Sons)
Year
2001
Tongue
English
Weight
161 KB
Volume
59
Category
Article
ISSN
0006-3525

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✦ Synopsis

A useful synthon to approach artificial phenylalanyl peptides in a [2 ϩ 2 ϩ 2] cycloaddition reaction, C ␣,␣ -dipropargylglycine (Dprg) is examined for its conformational preferences as a constrained residue. Crystal structure analysis and preliminary NMR results establish possible preference of the residue for folded (␣) rather than extended (␤) region of the ,

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