Conformational constraints on side chains in protein residues increase their information content

Conformational constraints of tyrosine i

Conformational constraints of tyrosine in protein tyrosine kinase substrates: Information about preferred bioactive side-chain orientation

✍ Paolo Ruzza; Andrea Calderan; Arianna Donella-Deana; Barbara Biondi; Luca Cesaro 📂 Article 📅 2003 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 139 KB

## Abstract The side‐chain orientation of a tyrosine residue located in a peptide, which is an excellent substrate of Syk tyrosine kinase (A. M. Brunati, A. Donella‐Deana, M. Ruzzene, O. Marin, L. A. Pinna, FEBS Letters, 1995, Vol. 367, pp. 149–152), was fixed in the gauche (+) or gauche (−) confor