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Conformational changes in a bacterial multidrug transporter are phosphatidylethanolamine-dependent

โœ Scribed by B. Gbaguidi; P. Hakizimana; G. Vandenbussche; J.-M. Ruysschaert

Book ID
105758590
Publisher
Springer
Year
2007
Tongue
English
Weight
762 KB
Volume
64
Category
Article
ISSN
1420-682X

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The multidrug resistance protein 1 (MRP1/ABCC1) is an ATPdriven transporter that mediates the cellular extrusion of various chemotherapeutic agents. We have previously isolated a novel recombinant single-chain Fv antibody (A5scFv), which specifically targets the extracellular N-terminus of the human