Conformational change at the active center of serine-proteases upon their binding to α2-macroglobulin

Activation of Akt/PDK signaling in macro

Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of α2-macroglobulin to its cellular receptor: Effect of silencing the CREB gene

✍ U.K. Misra; Salvatore V. Pizzo 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 403 KB

Macrophage binding of receptor-recognized forms of a 2 -macrogobulin (a 2 M\*) significantly increases cAMP, CREB, and activated CREB. We have now examined the participation of the PI 3-kinase/PDK/Akt/p70s6k signaling cascade in a 2 M\*-induced cellular proliferation and also studied the role of CRE