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Conformational aspects of polypeptide structure. XLI. Crystal structure of S-thiazolidine-4-carboxylic acid and helical structure of poly[(S)-thiazolidine-4-carboxylic acid]

✍ Scribed by Murray Goodman; Vera Chen; Ettore Benedetti; Carlo Pedone; Paolo Corradini

Publisher
Wiley (John Wiley & Sons)
Year
1972
Tongue
English
Weight
438 KB
Volume
11
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

The helical structures of poly[(S)‐thiazolidine‐4‐carboxylic acid], in the cis and trans forms, were redetermined by using the new sets of bond angles and bond lengths established by X‐ray diffraction analysis of L‐thioproline. Calculations of the helical structures of poly‐L‐proline and poly[(S)‐oxazolidine‐4‐carboxylic acid] were also repeated. As a result of these energy calculations, it is suggested that, in contrast to poly‐L‐proline and poly[(S)‐oxazolidine‐4‐carboxylic acid], poly[(S)‐thiazolidine‐4‐carboxylic acid] should not mutarotate from the trans to the cis form. This result is due to the fact that the energy barrier for the conversion is most likely too high. Previous experimental work is consistent with this finding.

📜 SIMILAR VOLUMES

Coformational aspects of polypeptide str
Coformational aspects of polypeptide structure XL. The synthesis of poly[(S)-thiazolidine-4-carboxylic acid]
✍ Murray Goodman; Kai-Chiang Su 📂 Article 📅 1972 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 371 KB

## Abstract The synthesis of poly[(__S__)‐thiazolidine‐4‐carboxylic acid] is described. The polymer is obtained by the polymerization of the __N__‐carboxyanhydride of (__S__)‐thiazolidine‐4‐carboxylic acid in pyridine or nitrobenzene using triethylamine as an initiator. The amino acid is prepared b