✦ LIBER ✦

Conformational aspects of inhibitor design: enzyme–substrate interactions in the transition state

✍ Scribed by Richard Wolfenden

Book ID: 108480696
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 223 KB
Volume: 7
Category: Article
ISSN: 0968-0896
DOI: 10.1016/s0968-0896(98)00247-8

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Conformational Preferences in the Transi

Conformational Preferences in the Transition States and Tetrahedral Intermediates of Transacylations. Relationships to Enzyme-Bound Conformations of Phosphonate Inhibitors of Lipases and Esterases

✍ Takano, Yu; Houk, K. N. 📂 Article 📅 2004 🏛 American Chemical Society 🌐 English ⚖ 713 KB

Solution conformations of KNI-272, a tri

Solution conformations of KNI-272, a tripeptide HIV protease inhibitor designed on the basis of substrate transition state: Determined by NMR spectroscopy and simulated annealing calculations

✍ Yasushi Ohno; Yoshiaki Kiso; Yuji Kobayashi 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 543 KB

KNI-272, a highly selective and potent HIV protease inhibitor containing allophenylnorstatine [(2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid], named Apns, has been studied in dimethylsulfoxide-d6 by NMR spectroscopy and simulated annealing calculations. 1H and 13C spectra showed the presence of two

[Part 2: Biological Sciences] || Conform

[Part 2: Biological Sciences] || Conformational Changes during Enzyme Catalysis: Role of Water in the Transition State

✍ Robert B. Loftfield, E. Ann Eigner, Andrzej Pastuszyn, Timo Nils Erik Lovgren an 📂 Article 📅 1980 🏛 National Academy of Sciences 🌐 English ⚖ 857 KB

Enzyme Architecture: Remarkably Similar

Enzyme Architecture: Remarkably Similar Transition States for Triosephosphate Isomerase-Catalyzed Reactions of the Whole Substrate and the Substrate in Pieces

✍ Zhai, Xiang; Amyes, Tina L.; Richard, John P. 📂 Article 📅 2014 🏛 American Chemical Society 🌐 English ⚖ 618 KB

Role of Enzyme−Ribofuranosyl Contacts in

Role of Enzyme−Ribofuranosyl Contacts in the Ground State and Transition State for Orotidine 5‘-Phosphate Decarboxylase: A Role for Substrate Destabilization? †

✍ Miller, Brian G.; Butterfoss, Glenn L.; Short, Steven A.; Wolfenden, Richard 📂 Article 📅 2001 🏛 American Chemical Society 🌐 English ⚖ 237 KB

Transition state stabilization and subst

Transition state stabilization and substrate strain in enzyme catalysis: ab initio QM/MM modelling of the chorismate mutase reaction

✍ Ranaghan, Kara E.; Ridder, Lars; Szefczyk, Borys; Sokalski, W. Andrzej; Hermann, 📂 Article 📅 2004 🏛 Royal Society of Chemistry 🌐 English ⚖ 314 KB