Conformational and linkage isomerizations for dihapto-coordinated arenes and aromatic heterocycles: controlling the stereochemistry of ligand transformations
✍ Scribed by W.Dean Harman
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 364 KB
- Volume
- 248
- Category
- Article
- ISSN
- 0010-8545
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✦ Synopsis
Arenes and aromatic heterocycles have cyclic skeletons made up completely of unsaturated carbons. Through their dihapto coordination to a transition metal, controlled addition reactions can be accomplished with good stereocontrol, relative to the position of the metal. The metal can readily undergo inter-and intrafacial linkage isomerizations in these complexes. By controlling these processes using chiral auxiliaries on the arene, stereogenic metal centers, or solid-state induced control of kinetically unstable stereoisomers (SICKUS), enantio-enriched organic compounds can be realized from this methodology. This work outlines what is known about conformational and linkage isomerizations in dihapto-coordinated aromatic complexes, and demonstrates their relevance to organic synthesis.