Conformational and enzymatic changes of 20S proteasome of rat natural killer cells induced by mono- and divalent cations

Activation of multiple caspases and modi

Activation of multiple caspases and modification of cell surface fas (CD95) in proteasome inhibitor-induced apoptosis of rat natural killer cells

✍ Min Lu; Richard P. Kitson; Yaming Xue; Ronald H. Goldfarb 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 159 KB

## Abstract The proteasome is a multi‐subunit protease complex that is involved in intracellular protein degradation in eukaryotes. Previously, we have reported that selective, synthetic chymotryptic proteasome inhibitors inhibit A‐NK cell‐mediated cytotoxicity by approximately 50%; however, the ex