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Conformational and dynamic investigation in solution of inosine and its molecular complex, inosiplex, by proton and carbon NMR spectroscopy

✍ Scribed by Claudio Rossi; Mariapia Picchi; Enzo Tiezzi; Gianfranco Corbini; Piero Corti

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
616 KB
Volume
28
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

The conformational and dynamic properties of inosine and two other components of inosiplex (p‐acetamidobenzoic acid and dimethylaminoisopropanol) were analysed. For inosine, the most interesting molecule of the complex, the rotamer populations of all six allowed structures related to the N ⇌ S puckering and the 5′‐exocyclic conformation were calculated. Analysis of different NMR spectra and/or parameters, i.e. 2D‐NOE, saturation transfer, spinlattice relaxation rates and scalar coupling constants, suggests that a distribution of several inosine structures occurs in solution, with the inosine syn conformation predominating.

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