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Conformational analysis of two cyclic disulfide peptides

✍ Scribed by C. García-Echeverría; G. Siligardi; P. Mascagni; W. Gibbons; E. Giralt; M. Pons

Publisher
Wiley (John Wiley & Sons)
Year
1991
Tongue
English
Weight
636 KB
Volume
31
Category
Article
ISSN
0006-3525

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✦ Synopsis

bonds have been carried out in different solvents to investigate the formation and stabilization of @-turn structures and to determine the stereochemistry of the disulfide linkage.

Both peptides have three-dimensional structures with a type I1 P-turn, as derived from quantitative nuclear Overhauser effect data. The combined use of CD and nmr indicates that the dihedral angle of the disulfide bridge is different in the two peptides, although the chirality is maintained.

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