Senecio v u l a r i s , a p l a n t c o n t a i n i n g 3 m a c r o f q c l i c p y r r o i z i d i n e a l k a l m A \* r o w n under atmospheric COZY CO , and 1JC02 c o n d i t i o n s . c o n d i t i o n s t h e p l a n t s were s u b j e c t e d t o and t h e amounts o f macrocyclic PAS i s o l
Conformational analysis of the pyrrolizidine alkaloid senecionine using molecular mechanics
โ Scribed by Hanson, Bryan A.; White, James D.
- Book ID
- 126867966
- Publisher
- American Chemical Society
- Year
- 1988
- Tongue
- English
- Weight
- 580 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
Pyrrolizidine alkaloid (PA)-containing plants are widely distributed in the world. PAs are hepatotoxic, affecting livestock and humans. PA N-oxides are often present together with PAs in plants and also exhibit hepatotoxicity but with less potency. HPLC-MS is generally used to analyze PA-containing
## Abstract The ^1^H and ^13^C NMR spectra of the pyrrolizidine alkaloid 13โ__O__โacetyldicrotaline were studied at 4.7 T. A full assignment of the ^1^H and ^13^C signals was achieved by application of a variety of NMR techniques, including homonuclear ^1^H NOE difference, 2D ฮด~H~/ฮด~H~ phaseโsensit
Conformational analysis of 20 neolignans was performed to determine the most probable conformer that may fit the receptor. The molecular ลฝ . mechanics method MM2 was employed to construct conformational maps in both a vacuum and a biological environment. Boltzmann's distribution among several local