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Conformational Analysis of Substituted N-Nitroso-trans-decahydroquinolin-4-ones

✍ Scribed by D. Natarajan; N. Bhavani; A. Manimekalai

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
197 KB
Volume
35
Category
Article
ISSN
0749-1581

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✦ Synopsis

1H and 13C NMR resonance assignments and conformational assignments were carried out for four N-nitroso-2phenyl-trans-decahydroquinolin-4-ones. In addition to conventional 1D NMR methods, 2D shift-correlated NMR techniques (1H-1H COSY, 1H-1H NOESY and 1H-13C HETCOR) were used for the signal assignments. At room temperature the title compounds exist in two isomeric forms. The preferred conformations of both the isomers of nitrosamines were determined by a comparison of the spectral data with those for the parent amines, and with the aid of substituent parameters. Molecular strain in nitrosamines is minimized by partial escape of the piperidine moiety into non-chair conformation. 1997

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